Federated Trusted
Research Environment 
(TRE)

Turn Data into Insights

Turn your data into insights without compromising security and privacy with Lifebit, the pioneer of the federated Trusted Research Environment (TRE).

Trusted by the world's biomedical leaders

What is a Trusted Research Environment?

Trusted Research Environments (TREs) are secure, controlled digital environments that provide researchers with safe, remote access to sensitive health data. Also known as “Data Safe Havens,” and “Secure Data Environments”, TREs allow approved users to access, analyze, and store data within a single secure location, ensuring patient privacy through strict access controls and pseudonymization.

Following the Five Safes Framework, TREs support collaborative research by facilitating access without compromising data security.

Fast, specialized data harmonization & product creation

Lifebit is trusted by top pharma and data providers for creating data products at scale.

Most secure TRE, by federated design

From the pioneers of federation, Lifebit’s TRE uniquely brings analysis and computation to where biomedical data resides.

Only TRE to guarantee results

The only solution for fast, accurate results through a TRE that is proven to handle datasets from over 250M+ patients.

Why Lifebit?​

The most widely adopted TRE on the market

Unmatched Usability and Security

in One Platform

Achieving both security and usability for biomedical data is crucial to accelerate research and drive meaningful innovation.

Security & Control: Sensitive biomedical data must be stored securely with strictly controlled access to prevent data & privacy breaches. The traditional approach of anonymizing and transferring patient data to a central computing location leads to loss of data control and introduces re-identification risk. The only way to fully secure patient data is to keep data and computation in the organization’s jurisdiction and environment where it can be monitored, ensuring full compliance with data residency and privacy regulations.

Usability & Data interoperability: Biomedical data is often fragmented, unstructured, and challenging to use. Researchers need data products that are fit-for-purpose and ready for analysis, along with a platform that enables joint queries across distributed databases, supporting collaborative research without unnecessary barriers.

Lifebit’s Trusted Research Environment (TRE) stands alone as the only federated data platform purpose-built for life sciences and biomedical data, combining complete usability and data integration with uncompromising security and control.

Impact

Safeguard your sensitive biomedical data with Lifebit’s Trusted Research Environment

MOVE FASTER

5x

Faster than other solutions to identify data, create cohorts, deploy pipelines and AI models & perform analyses.

GET GUARANTEED RESULTS

100%

of our clients get results. Lifebit’s Platform is the only TRE to contractually guarantee results.

OVERCOME COMPLIANCE OBSTACLES

100%

Data stays in your environment, ensuring data security compliance and reducing risk.

How it works

1. Create Workspaces and invite users

Create Workspaces and invite users Lifebit’s TRE enables data admins to set up and manage Organizations and Workspaces in under 10 minutes, automatically connecting to your cloud and network with top-tier security configurations. Designed and tailored for seamless collaboration, the TRE offers self-service capabilities with customizable settings, role-based access control, integrated communication tools, and scalable solutions, ensuring every team member has the right access and resources.

TRE Step 1

Collaborative and secure research, discovery and translation

Segment solutions

Lifebit’s Trusted Research Environment offers a broad range of use cases across segments
Public Sector Initiatives

TRE enabling controlled access to biomedical data

Controlled data access & sharing

Population genomics research

Cohort building & analysis

Data commercialization

Federal Health

TRE for sensitive data analysis

Controlled data access & sharing

Internal R&D

Cohort building & analysis

Data Providers

TRE for secure and controlled clinico-genomic and real world data

Controlled data access & sharing

Data commercialization

Health Nonprofit

TRE for storage, computing and multi-omics data analysis

Multi-omics data analysis

Population genomics research

Controlled data access & sharing

Data commercialization

Pharma & Biotech

TRE for multi-modal data analysis

Multi-omics data analysis

NGS data processing

Target identification & discovery

Patient subtyping stratification

Controlled data access & sharing

Securely protecting your sensitive biomedical data.

End-to-End Data Governance and Security by Design

based on the most advanced federated architecture in the industry

Ready to collaborate on distributed data?

Contact Lifebit today and discover how our federated data solutions can accelerate your research.

We’ll respond as soon as possible.

FAQs

What is data federation?

Data federation is a software process that enables numerous databases to work together as one. Using this technology is important for accessing sensitive biomedical health data, as the data remains within appropriate jurisdictional boundaries, while metadata (information about the data) is centralised and searchable.

Data federation is an alternative to a model in which data is moved or duplicated then centrally housed – when data is moved it becomes vulnerable to interception and movement of large datasets is often very costly for researchers. Instead, approved users may access the data via linking technologies such as Application Programming Interfaces, or APIs.

What is Federation Platform-as-a-Service?

A Federation Platform-as-a-Service (FedPaaS) is a secure, cloud-based service model that enables organizations to access and analyze data directly in their own cloud environment—without moving or duplicating the data. Unlike traditional bioinformatics platforms that require data to be transferred to the provider’s cloud account, Lifebit’s FedPaaS keeps data and computation within the organization’s own infrastructure. 

This model allows organizations to:
Maintain Full Control: Data stays in your organization’s cloud account, giving you full ownership and control without data exposure to shared environments.
Ensure Data Residency Compliance: Data remains within your jurisdiction and infrastructure, which is essential for compliance with data residency and privacy regulations.
Optimize Cloud Costs: Since data remains in your cloud account, you avoid the added costs and markups of external cloud storage and compute fees, and you leverage your own provider discounts.
Avoid Costly Data Transfers: If your relationship with the FedPaaS provider changes, there are no egress fees or data migrations needed—your data always remains in your environment.

How does Lifebit guarantee data security?

With Lifebit’s platform patient level data never moves thanks to its enterprise-grade federated architecture that keeps data in-place, and that adheres to the highest global security standards, including FedRamp, GDPR, HIPAA, ISO, and SOC II. We also implement the 5 Safes Framework to ensure strict data residency and secure access, making us the trusted choice for government and regulated industries.